Investigators

Research Profiles:

1. Oral and maxillofacial oncology

2. Reconstruction of head and neck defects

3. Biomarker of oralsquamous cell carcinoma (OSCC)

4. Immunology oforal squamous cell carcinoma

Research Expertise

Area of Research Expertise:

1. 28 years professional experiences in diagnosis and treatment of oral & maxillofacial, and head and neck tumors

2. Reconstruction of post-operation tissue defects in oral and maxillofacial region

3. Treatment of oral and maxillofacial hemangioma and vascular malformation

4. Microsurgery

5. 20 years study on oralsquamous cell carcinoma

Research Theme:

1. Study of the non-coding RNA regulation in oral squamous cell carcinoma

2. Development of biomarkers for early detection of precancerous lesions and diagnosis of OSCC

3. Discovery of regulatory factors in OSCC carcinogenesis

4. Development of novel approaches for effective cancer therapy

Academic Publications(10 most recent)

1.  Li, X.; Zhang, H.; Wang, Y.; Sun, S.; Shen, Y.; Yang, H. Silencing circular RNA hsa_circ_0004491 promotes metastasis of oral squamous cell carcinoma. Life Sci. 2019, 239, 116883.

2.  Su, W.; Wang, Y.; Wang, F.; Zhang, B.; Zhang, H.; Shen, Y.; Yang, H. Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma. J. Cell. Physiol. 2019, 234, 15156–15166.

3.  Su, W.; Tang, J.; Wang, Y.; Sun, S.; Shen, Y.; Yang, H. Long non-coding RNA highly up-regulated in liver cancer promotes epithelial-to-mesenchymal transition process in oral squamous cell carcinoma. J. Cell. Mol. Med. 2019, 23(4): 2645-2655.

4.  Su, W.; Wang, Y.; Wang, F.; Sun, S.; Li, M.; Shen, Y.; Yang, H. Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway. BMC Cancer 2019, 19, 400.

5.  Wang, Z.; Tang, J.; Wang, Y.; Sun, S.; Chen, Y.; Shen, Y.; Yang, H.-Y. Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma. Onco Targets Ther 2019, 12, 4025–4031.

6.  Su, W.; Sun, S.; Wang, F.; Shen, Y.; Yang, H. Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway. J Transl Med 2019, 17, 76.

7.  Wang, Y.-F.; Li, B.-W.; Sun, S.; Li, X.; Su, W.; Wang, Z.-H.; Wang, F.; Zhang, W.; Yang, H.-Y. Circular RNA Expression in Oral Squamous Cell Carcinoma. Front Oncol 2018, 8, 398–408.

8.  Sun, S.; Li, B.; Wang, Y.; Li, X.; Wang, P.; Wang, F.; Zhang, W.; Yang, H. Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma. Dis. Markers 2018, 2018, 6514795.

9.  Fang, Z.; Zhang, S.; Wang, Y.; Shen, S.; Wang, F.; Hao, Y.; Li, Y.; Zhang, B.; Zhou, Y.; Yang, H. Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins. BMC Cancer 2016, 16, 706.

10. Yang, Y.-T.; Wang, Y.-F.; Lai, J.-Y.; Shen, S.-Y.; Wang, F.; Kong, J.; Zhang, W.; Yang, H.-Y. Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma by regulating the WNT/β-catenin signaling pathway. Cancer Sci. 2016, 107, 1581–1589. 

Honours and Awards

1. President of Shenzhen Dental Association

2. Director of Stomatological Center of Peking University Shenzhen Hospital

3. Director of Oral and Maxillofacial Surgery of Peking University Shenzhen hospital

4. Vice president of Guangdong Dental Association

5. Member of Chinese Stomatological Association of oral and maxillofacial surgery

6. Standing Council Member of Guangdong Society of oral and maxillofacial surgery Council Member of Guangdong Stomatological Association

7. Executive director of Shenzhen Stomatological Association

8. The Shenzhen Science and Technology Progress Award (Class II) Shenzhen Science and Technology Innovation Committee  2014